Horner Lab - Institute for Stem Cell Biology and Regenerative Medicine
Philip Horner, PhD is a Professor of Neurological Surgery. His research focuses on stem cells as a basis for regeneration in spinal cord injury. This translation of a new and exciting area of basis research to a major clinical problem has been of great interest to the more recent neurosurgeon-neuroscientist and basic science trainees. He has collaborative projects with Dr. Morrison and Dr. Rostomily and has multiple National Institutes of Health (NIH) grant research support.
- Implications of aging on stem cells
- Stem cells and spinal cord injury
- Can stem cells replace lost cells in spinal cord injury?
- Does aging negatively impact endogenous stem cells?
- Can we manipulate retinal glia to preserve retinal ganglion cells in Glaucoma?
- Quantative morphology in the optic nerve
- Brain tissue processing for cellular analysis
- RNA/DNA analysis for gene expression
Bibliography of Selected Publications
- Inman, D.M, R.M. Sappington, P.J. Horner and D.J. Calkins. 2005.Quantitative Correlation of Optic Nerve Pathology with Ocular Pressure and Corneal Thickness in the DBA/2J Mouse Model of Glaucoma. IOVS 47(3):986-96. PMID: 16505033
- Steele, M.R., D.M. Inman, D.J. Calkins, P.J. Horner, M.L. Vetter. 2005. Microarray Analysis of Retinal Gene Expression in the DBA/2J Model of Glaucoma. IOVS 47(3):977-85. PMID: 16505032
- Inman, D.M. and P.J. Horner. 2007. Reactive Non-Proliferative Gliosis Predominates in a Chronic Model of Glaucoma. Glia, 55(9):942-53. PMID: 17457855
- Petit, A., D.L. Sellers, D. J. Liebl, M. Tessier-Lavigne, T.E. Kennedy, P.J. Horner. 2007. Adult Spinal Cord Progenitor Cells are repelled by netrin-1 in the embryonic and injured adult spinal cord. Proc Natl Acad Sci U S A. 2007 Nov 6;104(45):17837-42. PMID: 17978191
- Buckingham, B., D. Inman, W. Lambert, E. Oglesby, D.J. Calkins, M. Steele, M. Vetter, N. Marsh-Armstrong and P.J. Horner. 2008. Progressive Ganglion Cell Degeneration Precedes Neuronal Loss in a Mouse Model of Glaucoma. Journal of Neuroscience, 28(11):2735-44. PMID: 18337403
- Soto., I., E. Oglesby, B.P. Buckingham, J.L. Son, E.D.O. Roberson, M.R. Steele, D.M. Inman, M.L. Vetter, P.J. Horner and N. Marsh-Armstrong. 2007. Retinal Ganglion Cells Down-regulate Gene Expression and Lose their Axons within the Optic Nerve Head in a Mouse Glaucoma Model. Journal of Neuroscience, 9;28(2):548-61. PMID: 18184797
- Jurate Lasiene, Aya Matsui, Yuhito Sawa, Fernando Wong, Philip J. Horner. 2009. Age-related myelin dynamics revealed by increased oligodendrogenesis and short internodes. Aging Cell, 2009. Apr;8(2):201-13. PMID: 19338498
- Lasiene, J., L. Shupe, S. Perlmutter, P.J. Horner. 2008. No evidence for chronic demyelination in spared axons following spinal cord injury in a mouse. Journal of Neuroscience, 9;28(15):3887-96. PMID: 18400887
- White, B.D., R.J. Nathe, D.O. Maris, N.K. Nguyen, J.M. Goodson, R.T. Moon, and P.J. Horner. 2009. bcatenin signaling increases in proliferating NG2+ progenitors and astrocytes during posttraumatic gliogenesis in the adult brain. Stem Cells. (2):297-307. PMID: 19960516
- Bosco, A., D.M.Inman, M.R.Steele, G.Wu, N.Marsh-Armstrong, D.J. Calkins, P.J. Horner, M.L.Vetter. 2008. Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma. IOVS, 49(4):1437-46. PMID: 18385061
- Drew L. Sellers, Don O. Maris, and P.J. Horner. 2009. Post-injury niches direct temporal shifts in progenitor fate-choice to direct niche succession and repair after spinal cord injury. Journal of Neuroscience, 29(20):6722-33. PMID: 19458241
- Baltan, S, D.M. Inman, C. Danilov, R.S. Morrisona D.J. Calkins, P.J. Horner. 2010. Metabolic vulnerability disposes axons to dysfunction in a model of glaucomatous degeneration. Journal of Neuroscience. 30(16):5644-52, PMID: 20410117, /with cover/
- Crish, S.D., R.M. Sappington, D.M. Inman, P.J. Horner and D.J. Calkins. 2010. Distal Axonopathy with Structural Persistence in Glaucomatous Neurodegeneration. Proceedings of the National Academy of Sciences, 107(11):5196-201, PMID: 20194762
For more information on the Horner Lab, contact Phil Horner at: firstname.lastname@example.org
Published Research Articles
View complete lists of current research publications by faculty from the Department of Neurological Surgery.